Recent work found that small nucleolar RNA host gene 3 (SNHG3) interacted with E2F1 and promoted its expression, which then promoted overexpression of NEIL3 by enhancing the binding ability of E2F1 and the NEIL3 promoter, ultimately promoting the malignant progression of HCC, and also suggested that SNHG3 and NEIL3 could be combined to assess the poor prognosis of HCC patients [74,75]. This evidence concerns the gene E2F1 and hepatocellular carcinoma.