We found that circNEIL3 inhibited the binding of IGF2BP3 to HECTD4 in vitro, which suppressed the ubiquitination degradation of IGF2BP3 by HECTD4, thus promoting the expression of IGF2BP3 protein and its downstream oncogenic proteins such as CDK4/6, CD44 and c-MYC, and ultimately promoting the proliferation, invasion and migration of GBM cells [91]. Here, HECTD4 is linked to glioblastoma.