Similarly, the PI3K/AKT/mTOR pathway, G2/M checkpoint and E2F proteins were abnormally activated in patients with high NEIL3 expression, and we speculate that NEIL3 may significantly enhance the proliferation, invasion and migration of NSCLC cells by activating the PI3K/AKT/mTOR signaling pathway in part [68] (Figure 4). This evidence concerns the gene NEIL3 and non-small cell lung carcinoma.