In a study on LUAD, NEIL3 overexpression was significantly negatively correlated with infiltration of B cells, CD4+ T cells and DCs in cancer tissues and significantly positively correlated with nTreg, iTreg, and exhausted T cells, suggesting that NEIL3 plays a crucial role in regulating immune infiltrating cells in LUAD and promotes the formation of a suppressive tumor microenvironment [67]. This evidence concerns the gene NEIL3 and cancer.