TP53 and neoplasm: In this regard, an in vivo study revealed that a xenograft HPV positive tumor mice model that was locally injected with liposomes containing a CRISPR-Cas9 knocking-down system for E6/E7 from HPV-18 and -16, recovered the expression of p53 and p21 tumor suppressors, followed by a reduction in tumor growth [39,40].