Furthermore, the affected brain regions of the substantia nigra and corpus striatum (where dopaminergic neurons reside) that are affected in PD, report extended activation of microglia which are suggested to drive the promotion of dopaminergic neuronal cell death due to the activation of the NLRP3 inflammasome complex, accompanied by the simultaneous increase in reactive ROS and nitrous oxide (NO) levels [15,35,36]. This evidence concerns the gene NLRP3 and Parkinson disease.