PARP1 and neurodegenerative disease: In addition, recent reports suggest a critical role of PARP1 in certain neurodegenerative diseases such as sporadic and familial forms of amyotrophic lateral sclerosis (ALS) and frontotemporal degeneration (FTD), since poly(ADP-ribose) is implicated in the accumulation of proteins causative of neurodegenerative disease in the motor neurons [26,27,28,29].