In a methicillin-resistant staphylococcus aureus-induced murine ALI model, the anti-inflammatory substance dehydrocostus lactone induced polarization of the macrophages from M1 to M2 by inhibiting the p38 MAPK/NF-κB signal and activating the Nrf2 signal [12]. The gene discussed is NFKB1; the disease is acute respiratory distress syndrome.