In contrast, hippocampal levels of the AEA synthesizing enzyme, NAPE-PLD, were reduced, and levels of the AEA-degrading enzyme, FAAH, were increased in SCA1 mice treated with Ro0711401, as compared to wild-type mice treated with the vehicle or Ro0711401 (Figure 6A,C). The gene discussed is FAAH; the disease is spinocerebellar ataxia type 1.