Although METTL3 is reported to promote translation in human cancer cells independent of its catalytic activity and m6A readers [38], the METTL3 knockdown resulted in a better association of our candidate mRNAs with polysomes, especially PHLDA1, PIDD1 and PMAIP1, under cisplatin treatment conditions (Figure 5). This evidence concerns the gene PIDD1 and cancer.