Zhuang et al. found that CCL2 could activate the hedgehog signaling pathway of HCC cells through the CCL2/CCR2 molecular axis, and up regulate the expression of snail and vimentin, as well as down regulate E-cadherin expression to promote HCC cell invasion and epithelial mesenchymal transition [12]. This evidence concerns the gene CCL2 and hepatocellular carcinoma.