For instance, CRH has been reported inducing apoptosis in neurons [32], in PC12 rat pheochromocytoma cell line [33], in microglial cells [34], in prostate cancer cell RM-1 [35] and in the mural granulosa cells (MGCs) of mouse ovarian follicles [36,37]. Here, CRH is linked to hereditary pheochromocytoma-paraganglioma.