DUSP4 is located downstream of VGF in the VGF network [14], and to better understand how DUSP4 functions in the multiscale network and contributes to AD pathogenesis and progression, we overexpressed DUSP4 in the dorsal hippocampus (dHc) of the 5xFAD mouse model of Alzheimer’s amyloidosis. This evidence concerns the gene DUSP4 and Alzheimer disease.