HLA-C and Alzheimer disease: Previous temporal gene profiling in the 5xFAD hippocampus and cortex revealed numerous overexpressed IFNγ-regulated transcripts, including those that encode chemokines, major histocompatibility complex (MHC) class I and II molecules, and regulators of the IFNγ pathway, autophagy and phagocytosis [47], which mirrors gene expression profiling in AD subjects [52,53].