To determine the sex-specific expression patterns in human AD brains of several key hub genes in the VGF multiscale gene network, including DUSP4, BDNF and VGF, we used our recently published RNAseq data in the parahippocampal gyrus (PHG) region of postmortem brains of AD subjects and controls from the Mount Sinai Brain Bank (MSBB). This evidence concerns the gene DUSP4 and Alzheimer disease.