CDK12 and cancer: The hypermethylation in OV had distinct features from other cancer types: a group of BRCAness genes of MER11A, RAD51, PALB2, CHD4, BRIP1, MYC, and FANCE were increasingly expressed whereas another group of WRN, CDK12, CHEK2, FANCA, and TP53 was decreasingly expressed (Figure 5C).