The hypermethylation in OV had distinct features from other cancer types: a group of BRCAness genes of MER11A, RAD51, PALB2, CHD4, BRIP1, MYC, and FANCE were increasingly expressed whereas another group of WRN, CDK12, CHEK2, FANCA, and TP53 was decreasingly expressed (Figure 5C). The gene discussed is BRIP1; the disease is cancer.