We searched for both germline and somatic pathogenic variants in BRCA1/2 and BRCAness genes in each of the 33 cancer types and identified a total of 808 germline and 4017 somatic pathogenic mutations in BRCA1, BRCA2 and 37 of the 38 BRCAness genes distributed in 33 cancer types. This evidence concerns the gene BRCA2 and cancer.