DAVID functional annotation analysis and KEGG pathway analysis revealed that the top 1000 genes negatively correlated with the expression of ADGRF5 are involved in various signaling pathways, including ribosome (hsa03010), which was the most significant signaling pathway (adjusted p < 0.00001) associated with the expression signature of ADGRF5 in CRC patients. This evidence concerns the gene ADGRF5 and colorectal carcinoma.