In the colons of CRC patients, we found genes such as AKT3, caveolin (CAV) 1 and 2, COL1A2, COL3A1, COL4A1, COL4A2, COL5A1, COL5A2, COL5A3, COL6A3, COL11A1, COL24A1, FLT1, HGF, ITGA1, ITGA4, ITGA5, ITGAV, ITGB1, ITGB3, KDR, LAMA4, LAMC1, myosin light chain kinase (MYLK), PDGFC, PDGFRA, PDGFRB, THBS2, TNC and VEGFC which are characterized by a positive correlation with ADGRF5 expression pattern, and participate in focal adhesion signaling pathway (Table 3). The gene discussed is ADGRF5; the disease is colorectal carcinoma.