On the contrary, numerous signaling pathways such as mitogen-activated protein kinase, phosphatidylinositol 3-kinase (PI3K), transforming growth factor-β (TGF-β), WNT, and Notch pathways are deregulated in CRC and play crucial roles in the regulation of proliferation and migration as well as invasion of CRC cells [3,4,5,6,7]. Here, WNK2 is linked to colorectal carcinoma.