In fact, in vitro analysis using CRC cells and siRNA against ADGRF5 documented that the silencing of ADGRF5 led to a reduction of CDH2, Snail family zinc finger transcriptional factor, phospho-Akt, and phospho-ERK 1/2 protein level suggesting that its role in the progression of CRC [19]. The gene discussed is ADGRF5; the disease is colorectal carcinoma.