In line with this, aging-related up-regulation of Rps6ka1, a hub gene in the senescent SAMP8 mice [83], is associated with Alzheimer’s disease development, and experimental down-regulation (as here demonstrated by late-onset EE), ameliorates associated deficits in synaptic plasticity and spatial memory [84] and increases the lifespan of S6K1−/− mice [85]. This evidence concerns the gene RPS6KA1 and early-onset autosomal dominant Alzheimer disease.