Fortunately, the use of anti-CD40 mAb on transgenic pig hearts (GTKOhTg.hCD46.hTBM) blocked the same CD40-CD40 ligand costimulation pathway to avoid thrombotic microangiopathy and allow for the successful survival of pig cardiac xenografts in baboons for 236 days [26]. This evidence concerns the gene CD40 and Genetic thrombotic microangiopathy.