After KD of MAGOH and MAGOHB using the siMAGOH/B Pool, a significant increase in GADD45A mRNA expression was observed in the cutaneous melanoma cell lines Mel Ho and 501Mel, whereas no obvious changes in the expression of GADD45B or GADD45G could be detected (Figure 6D). The gene discussed is MAGOHB; the disease is cutaneous melanoma.