To investigate if this mechanism is responsible for the observed apoptosis after KD of MAGOH and MAGOHB in melanoma cells, we transfected the siPool targeting both homologues (siMAGOH/B Pool) into the cutaneous melanoma cell lines Mel Ho and 501Mel and measured the mRNA levels of Bcl-XS and Bcl-XL using qRT-PCR. The gene discussed is MAGOH; the disease is melanoma.