ARH2 involvement in human disease: Whole-genome sequencing revealed that the ARH2/ADPRHL1 missense variant p.Leu294Arg in ARH2/ADPRHL1 is associated with left anterior fascicular block (LAFB) using 405,732 electrocardiograms from 81,192 Icelanders [84]. The gene discussed is LDLRAP1; the disease is heart disorder.