We conducted a case–control study of Lithuanian subjects to evaluate associations between relative leukocyte telomere length, genetic variants in telomere-related genes (TERT rs2736098, rs401681 in TERT-CLPTM1 locus, TRF1 rs1545827, rs10107605, TNKS2 rs10509637, rs10509639, and TRF2 rs251796), and serum TERF-1 and TERF2 levels on the risk of age-related macular degeneration development. This evidence concerns the gene CLPTM1 and age-related macular degeneration.