CCND1 and acromegaly: Differences between transcriptomic groups were also observed in expression levels of proliferation-related genes CCND1 [34], CDKN1B [27], and MKI67 [35] and genes involved in cell signaling TGFB1 [36] and STAT3 [37] that all have a reported role in acromegaly patients’ outcome (Figure 4B).