CCL2 and neoplasm: DARC can internalize chemokines (i.e., CCL2, CCL11, CXCL1, CXCL2, CXCL3, CXCL5, CXCL7, CXCL8) that promote angiogenesis or formation of blood vascular, which can foster tumor growth, as well as promote endothelial cell survival via inhibiting apoptosis [132,188,189].