Since, as previously mentioned, the Duffy null allele is significantly more prevalent in individuals of West African ancestry and their weaker antitumor immune response has been suggested to underlie their poor prognosis, the lack of DARC expression among Black/AAs could be associated with their faster rates of inflamm-aging and, therefore, higher incidence rates of breast cancer and mortality at a younger age compared to individuals of European ancestry. This evidence concerns the gene ACKR1 and breast cancer.