A mutation in the promoter of the GATA box in the DARC gene removes DARC expression from erythrocytes, which is known as the Duffy-null allele [13,16,17].” The majority of the West African population harbor this mutation at a 100% fixed allelic frequency and, thus, are resistant to P. vivax-induced malaria [18]. Here, ACKR1 is linked to malaria.