DARC can internalize chemokines (i.e., CCL2, CCL11, CXCL1, CXCL2, CXCL3, CXCL5, CXCL7, CXCL8) that promote angiogenesis or formation of blood vascular, which can foster tumor growth, as well as promote endothelial cell survival via inhibiting apoptosis [132,188,189]. Here, CXCL1 is linked to neoplasm.