After the initial identification of LASP1 in the lymph nodes of breast cancer patients in 1995, investigations over the last 20 years suggested a critical role of the protein in cancer biology, mainly in tumor progression and the metastatic cascade including currently defined roles in chemokine receptor regulation, AKT signaling, Snail1 stability, and modulation of gene expression levels (Figure 5). The gene discussed is LASP1; the disease is cancer.