ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive: Breast cancer cells show high levels of LASP1 phosphorylated at S146 by PKA, while in chronic myeloid leukemia (CML) cells a dominant phosphorylation of LASP1 at Y171 by the constitutively active BCR-ABL tyrosine kinase was observed [11].