ENPP2 and malignant colon neoplasm: For example, a 54-kb region in between the cellular communication network factor 3 (CCN3 or NOV) and ectonucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2) genes on chromosome 8q24 has been suggested to be associated with the development of breast cancer [20] and co-expression gene patterns during colon cancer metastasis [21].