Although several members of the CanCord34 genes have been reported to be sporadically upregulated in human cancer and the fact that 11 (i.e., SHARPIN, HSF1, BOP1, HGH1, EXOSC4, ZC3H3, DGAT1, MAF1, PUF60, PYCR3, and GPAA1) of the CanCord34 genes are part of the pan-cancer SARPIN signature of 20 genes [6], the notion of continuously organized, co-overexpressed protein-coding CanCord34 genes at a single locus was described here for the first time. This evidence concerns the gene EXOSC4 and cancer.