OGG1 and neoplasm: The quantity of 8-oxoG in DNA and G:C→T:A transversion mutations were significantly higher in Ogg1 knockout mice than in wild-type mice, and in the 18 months following birth, the incidence of spontaneous lung adenoma/carcinoma was significantly elevated in Ogg1 knockout mice, and the percentage of tumor-bearing Ogg1 knockout mice was also 5 times higher than that observed in wild-type mice [65].