For example, the recent findings of Zhou et al. [81] suggested that OGG1 Ser326Cys polymorphism may be a risk factor for lung, digestive system and head and neck cancers; nevertheless, no association was observed in breast, prostate and bladder cancers, and the association between OGG1 Ser326Cys polymorphism and the susceptibility of digestive system cancers was found to only exist in Asian populations. Here, OGG1 is linked to head and neck cancer.