OGG1 and neoplasm: For instance, Wang et al. found that treatment with alantolactone, a natural compound that inhibits thioredoxin reductase to induce ROS accumulation, could lead to increased 8-oxoG in tumor cells, and the inhibition of OGG1 by the knockdown, or addition, of an OGG1 inhibitor and significantly improve cell viability [112].