TFEB and cancer: The cellular protective effects of TMBIM6 are first described by Chae et al., where protective effects were attributed to enhanced PRKAA phosphorylation, the regulation of MTORC1 activity, and the activation of PPP3/calcineurin, stimulation of TFEB (transcription factor EB) nuclear translocation that enhances autophagy flux in cancer cells [177,178,179].