In this context, we have observed the increased level of PINK1, p53, pJNK1 and HSP75/TRAP1 in neuronal cells upon neurotoxin exposure, which was inhibited in Myc-UBA52 transfected cells even after PD induction, suggesting the involution of UBA52 in HSP90 and its client proteins interaction during PD onset (Figure 8a). This evidence concerns the gene MYC and Parkinson disease.