UBC and Parkinson disease: The age-related movement disorder Parkinson’s disease (PD) is caused due to the loss of dopaminergic neurons of the substantia nigra in the midbrain [1,2,3] The neuropathological hallmarks of the disease include Lewy bodies containing protein (α-synuclein, ubiquitin, chaperones) aggregates, reflecting the impaired protein degradation mechanisms such as ubiquitin-proteasome system (UPS) and autophagy [2].