In this context, we have observed the increased level of PINK1, p53, pJNK1 and HSP75/TRAP1 in neuronal cells upon neurotoxin exposure, which was inhibited in Myc-UBA52 transfected cells even after PD induction, suggesting the involution of UBA52 in HSP90 and its client proteins interaction during PD onset (Figure 8a). The gene discussed is UBA52; the disease is Parkinson disease.