In this study, it is demonstrated that the mitochondrial pool of FKBP51 rapidly migrates to the nucleus upon the onset of oxidative stress, a situation that mimics the metabolic state of cancer cells [21], and it is also observed when undifferentiated neuronal cells are stimulated with FK506, a ligand that triggers neurodifferentiation in vitro and in vivo conditions [42]. This evidence concerns the gene FKBP5 and cancer.