AMOTL2 and cancer: In line with this advantageous effect of the immunophilin for cancer cell survival and cancer cell division, it has also been reported the presence of FKBP51 in nuclear heterocomplexes of Amotl2 (angiomotin-like 2) and IQGAP1 (IQ-motif-containing GTPase-activating protein 1), factors that are involved in the regulation of cell growth, tumorigenesis, inflammation, immunity, cell plasticity and differentiation [30].