RTN4 and Alzheimer disease: In another model for AD, 15-month-old APP/PS1 transgenic mice showed diminished capability of microglial cell migration to amyloid beta (Aβ) fibril deposition mediated through the Nogo-A/NgR-dependent mechanism [21], indicating that in the aged brain, Nogo-A/NgR stimulation can affect inflammatory mechanisms within the CNS.