Consistently, in progressive MS post-mortem brain tissues, NgR1 was strongly expressed in astrocytes and in more than 60% of microglia at the site of chronic active and inactive demyelinating injury, with these glial cells also expressing both of the putative NgR-dependent co-receptors, TROY and LINGO 1 [142,143,156]. Here, RTN4R is linked to myeloid sarcoma.