ACTA1 and ovarian cancer: A t-SNE plot of the ovarian cancer single-cell RNA sequencing profile of the tumor microenvironment [23] shows that COL11A1, ACTA2 (gene encoding for α-SMA), and PDPN are expressed in different, partially overlapping, ovarian CAF subsets, with COL11A1 exhibiting the most restricted expression (Figure 3A).