CLPS and chronic obstructive pulmonary disease: Another understudied area is the role of chitinases and CLPs as potential novel treatment targets for COPD; considering that the efficacy of chitinase inhibitors is currently being investigated for the treatment of lung diseases in in vitro and animal models [14] and that therapeutic options in COPD are still limited and unsatisfactory in terms of effectiveness, targeting chitinases and CLPs is an attractive possible solution.