While this study is the first to associate COL22 with the outcome in PDAC, the results are in line with what has been shown for COL22 in squamous cell carcinoma of the head and neck, where the mRNA expression of COL22A1 was significantly increased and associated with an earlier disease recurrence and thus a shorter disease-free survival [47]. Here, COL22A1 is linked to squamous cell carcinoma.