LAT1, which is overexpressed on both the BBB and glioma cells, was selected as a target and modified glutamate-d-α-tocopherol polyethylene glycol 1000 succinate copolymer (Glu-TPGS) in liposomes to enhance the BBB penetration and glioma therapy [29]. The gene discussed is SLC7A5; the disease is central nervous system cancer.