Metabolic dysfunction has been reported in RGCs from glaucoma patients and in animal models [2,4,5,40,41,42], and we have reported the sensitivity of MG to OHT-associated hypoxia [31,32], so we examined the impact of MG-specific COX10 knockout on RGC survival following 4 weeks of ocular hypertension. This evidence concerns the gene COX10 and ocular hypertension.