Under hypoxic exposure, white adipocytes potentiate TNF-α-induced upregulates expression of inducible NO synthase and cyclooxygenase-2(COX2), and downregulates peroxisome proliferator-activated receptor γ (PPARγ) and peroxisome proliferator-activated receptor gamma coactivator-1 α (PGC-1α) levels, which is closely associated with inflammation in adipocyte induced by hypoxic under the circumstance of obesity [112]. The gene discussed is PTGS2; the disease is obesity due to melanocortin 4 receptor deficiency.