It binds to the leukotriene B4 receptors, BLT1 and BLT2 and recent advances have unraveled the function and structures of BLT1 and BLT2 in mediating inflammatory responses [184,185], as well as BLT1 in hepatocytes promotes NAFLD development in obesity [186]. Here, LTB4R is linked to obesity due to melanocortin 4 receptor deficiency.