Proteins with a “degree” value higher than 31 were selected as the significant targets, which included proto-oncogene tyrosine-protein kinase (SRC), heat shock protein 90 alpha family class A member 1 (HSP90AA1), estrogen receptor 1 (ESR1), hypoxia inducible factor 1 subunit alpha (HIF1A), vascular endothelial growth factor A (VEGFA), silent information regulator 1 (Sirt1) and prostaglandin endoperoxide synthase 2 (PTGS2), all of which may play an important role in DHM’s action against depression. The gene discussed is ESR1; the disease is depressive disorder.