Since DHM has been shown to enhance BDNF expression in two other depression rodent models [29,30], it is reasonable to conclude that DHM also stimulates BDNF expression, controls the AGE-RAGE–NF-κB axis, and inhibits inflammation in the hippocampus of CORT-exposed mice, which is worthy of further investigation. Here, NFKB1 is linked to major depressive disorder.