Emerging clinical and genetic data now show that aberrant expression and function of the SKP1-CUL1-F-box (SCF; S-Phase Kinase Associated Protein 1 [SKP1] and Cullin 1 [CUL1]) complex induces CIN that may have pathogenic implications in various cancer contexts [10,11,12,13,14,15]. This evidence concerns the gene CUL1 and cancer.