SKP2 and cervical squamous intraepithelial neoplasia: Collectively, the dynamic and significant changes in nuclear areas and micronucleus formation, coupled with the ongoing changes in chromosome complements, confirm SKP2 as a novel CIN gene in non-malignant/non-transformed colonic epithelial cells and further suggest that SKP2 copy number losses may be an early etiological event contributing to CRC development.