Prior to assessing the impact reduced SKP2 expression has on CIN, we first assessed the silencing efficiencies of individual (siSKP2-1, -2, -3, -4) and pooled (siSKP2-Pool) siRNA duplexes in HCT116, a karyotypically stable CRC cell line. Here, SKP2 is linked to cervical squamous intraepithelial neoplasia.