Mesenchymal stem cells engineered to express TRAIL (MSC-TRAIL) induce apoptosis more potently than soluble TRAIL [198] and have been found to induce apoptosis in sarcomas, tongue squamous cell carcinoma, glioblastoma, and TNBC brain metastases in vitro and in vivo [199,200,201,202]. Here, TNFSF10 is linked to tongue squamous cell carcinoma.