Interestingly, CDK9 inhibition has also been shown to increase TRAIL mediated apoptosis in other cancer models by downregulating the anti-apoptotic regulators MCL-1 and FLIP, thus indicating that inhibition of CDK9 sensitizes cells to TRAIL through regulation of components of the extrinsic and intrinsic pathway [172]. The gene discussed is TNFSF10; the disease is cancer.