TNFRSF10B and cancer: In this study the investigators found that DR5 was upregulated in the bone tropic cells compared to the parental MDA-MB-231 cell line and they demonstrate that RNAi mediated knockdown of DR5 reduces the levels of bone metastasis related genes (e.g., HMGA2, phosphor-Src, and the C-X-C cytokine receptor 4) in the cancer cell.