A paclitaxel (PTX)-bound albumin nanoparticles with embedded TRAIL (TRAIL/PTX HSA-NP) formulation based on paclitaxel-bound albumin nanoparticles embedded with TRAIL showed improved TRAIL efficacy both in vitro and in vivo pancreatic cancer models [214]. The gene discussed is TNFSF10; the disease is familial pancreatic carcinoma.