Altogether, these findings reveal a new regulatory mechanism of HIF-1α in BM macrophages during the efferocytosis of apoptotic prostate cancer cells where the p-STAT3/HIF-1α/MIF signaling pathway induces inflammation, a mechanism that would be activated in the bone tumor microenvironment comprising a significant number of apoptotic cancer cells. Here, STAT3 is linked to prostate carcinoma.