POMC and pituitary gland adenoma: Studies on human subjects with ACTH-secreting pituitary tumors also revealed metabolic changes: one study reported on 12 initially significantly changed metabolites in pituitary adenoma samples when compared to the control samples; after performing a Bonferroni correction, there were only three metabolites significantly changed: pyridoxate, deoxycholic acid, and 3-methyladipate [47].