Naringenin enhanced the integrity of the intestinal barrier by increasing the expression of occludin and claudin-4 in Caco-2 cells [51]; prevented hyperglycemic-induced oxidative stress and membrane leakage in Caco-2 cells [52]; and supplementing naringenin ameliorated the DSS-induced colitis through protection of the tight junction barrier and the anti-inflammatory effect [53]. The gene discussed is CLDN4; the disease is colitis.