IGHE and wheat allergic reaction: ω-5 gliadin is also reported to be the major allergen of WDEIA, and its major IgE-binding epitope sequence QQX1PX2QQ (X1 is I, L, F, S or Y; X2 is Q and E) has been obtained from patients with WDEIA from Japan and Europe [8,9,10], and these epitopes are also present in pediatric patients with wheat allergy with urticaria or anaphylactic shock [11].