IGHE and food allergy: When intestinal barrier integrity is disrupted, sensitization to food allergens can occur, causing a T-helper (Th) 2-mediated immune response, which results in antigen-specific IgE antibodies binding to Fcε receptors on mast cells and basophils, and cross-link with the allergens, initiating the degranulation process, releasing β-hexosaminidase (β-Hex), histamine and other preformed mediators, which causes food allergy symptoms [25].