Food allergy increased the risk of STZ-induced diabetes in mice, which promoted food allergen-induced damage of the jejunum barrier and direct uptake of dendritic cells, induced mast cell activation, increased IL-4, IL-5, IL-6, mMCP-1, and TNF-α secretion, reduced GLP-1 secretion in the jejunum, and decreased insulin secretion in the pancreas. Here, GLP1R is linked to food allergy.