For example, it was reported that the selenylated tea polysaccharides induced cell apoptosis through the mitochondrial pathway, as well as intracellular ROS production, increasing the Bax/Bcl-2 ratio and caspases-3/-9 activation [37], while the selenylated polysaccharides of ginseng also caused cell apoptosis in human promyelocytic leukemia (HL-60) cells via the mitochondrial-mediated pathway [38]. Here, BAX is linked to acute promyelocytic leukemia.