If validated in prospective larger cohorts, the predicted trajectories through the implementation of a neural network will represent a breakthrough in clinical screening and swift detection of FXTAS morbidity in carriers of the FMR1 premutation without overt FXTAS symptoms or to prevent the transition to stages with more detrimental symptoms and co-morbidities. The gene discussed is FMR1; the disease is fragile X-associated tremor/ataxia syndrome.