Firstly, when we compared the genetic correlation (Supplementary Fig. 1), and the MTAG results (Supplementary Fig. 2) before and after excluding genomic regions (HLA, ASIP, IRF4, MC1R, SLC45A2 and CDKN2A) with very large effect sizes for skin cancers and pigmentation traits, and there was a high concordance (Supplementary Fig. 2). Here, IRF4 is linked to skin cancer.