Addition of dietary iron overload to the Western diet feeding resulted in hypertriglyceridemia, hypercholesterolemia, hepatic iron accumulation, increased hepatic lipid peroxidation, and exacerbation of hepatic inflammation with upregulation of M1-related cytokines and nuclear translocation of NFκB in the present WD + Fe model. The gene discussed is NFKB1; the disease is familial hypercholesterolemia.