Moderate to intense immunoreactivity was seen in the nucleus and cytoplasm of inflammatory cells in the microgranulomas (Fig. 7f, g; black arrows) and large inflammatory foci (Fig. 7f, g; black arrowheads) in WD and WD + Fe groups; some hepatocytes around the inflammatory foci had nuclear immunoreactivity of NFκB (Fig. 7f, g; white arrows). Here, NFKB1 is linked to Wilson disease.