The reported pathogenic variants in the FLT4 gene related to lymphedema and Milroy disease are summarized in Table 1 [19, 24–39], and the reported pathogenic variants in the PTPN11 gene related to Noonan syndrome and LEOPARD syndrome are summarized in Table 2 [40–55]. This evidence concerns the gene PTPN11 and Noonan syndrome with multiple lentigines.