In vitro experiments demonstrated that lipid droplets were decreased, and cell invasion, migration and proliferation were inhibited when we used siRNA to knock down the expression of SREBF1 or FASN. These observations suggest that dysregulated lipid metabolism induced lipid droplets accumulation after PM2.5 exposure may play an important role in the occurrence and progression of lung cancer and that blocking or correcting lipid metabolism dysregulation may be a potential intervention strategy for reducing lung cancer risk associated with PM2.5 exposure. Here, SREBF1 is linked to lung cancer.