CD4 and Parkinson disease: We finally analyzed the data separately for drug naïve and levodopa-treated PD patients, and noticed comparable changes of SOX and TMRE showing the same trend, while ROS was significantly reduced in activated CD4+ T cells derived from drug naïve PD patients (Interaction, F(1, 20) = 5107 p = 0.0351; activation, F = 7920 p = 0.0107; PD, F = 2737 p = 0.1137) (Supplementary Fig. 3).