LYVE1 and melanoma: While the number of hepatic metastases of WT31 melanoma was decreased in Lyve-1-KO compared to Ctrl mice (P = 0.0408) (Fig. 3D), the number of pulmonary WT31 melanoma metastases was not altered in Lyve-1-KO in comparison to Ctrl mice, indicating a specific role of Lyve-1 in liver but not lung colonization of melanoma (Additional file 1: Figure S3B).