Tumor-free Lyve-1-KO livers showed increased numbers of CD4+ T cells (P = 0.0094), CD8+ T cells (P = 0.0449), regulatory T cells (Treg) (P = 0.0389) and eosinophils (P = 0.0139) compared to Ctrl livers, whereas other immune cell subtypes remained unchanged (Fig. 5A; Additional file 1: Figure S6B). This evidence concerns the gene CD4 and neoplasm.