Compared to the patients with normal thyroid function, we found patients combined with thyroid dysfunction had a significantly higher percentage of nephrotic syndrome (67.0% vs. 51.7%, P = 0.009), presenting with more proteinuria (6.0, 2.5–9.6 vs. 4.4, 2.2–6.6 g/24 h, P = 0.001), a higher level of serum cholesterol (8.1, 6.4–10.2 vs. 6.8, 5.6–8.4 mmol/L, P < 0.001), while a lower level of serum albumin (21.3 ± 6.9 vs. 25.1 ± 6.6 g/L, P < 0.001). The gene discussed is ALB; the disease is nephrotic syndrome.