Notably, the rescue of neutropenia in the competitive transplant setting (Supplementary Fig. 4A) resulted in the normalization of Sca1 and Iigp1 levels (Supplementary Fig. 4E), confirming that reduction in IFN signaling was a consequence of neutropenia and not HSPC intrinsic alterations. Here, IFNA1 is linked to Decreased total neutrophil count.