Recipients of the Cebpacre/+R26EYFP/+SbdsF/F fetal liver cells (hereafter SbdsF/F or mutants) developed profound neutropenia with an absolute neutrophil count (ANC) of 0.15 ± 0.05 × 103/μL vs. 0.70 ± 0.20 × 103/μL in recipients of the Cebpacre/+R26EYFP/+Sbds+/+ fetal liver cells (hereafter Sbds+/+ or controls), which was stably sustained until sacrificing the animals at 4 months post-transplant (Fig. 1A–C), confirming our previous findings23. Here, SBDS is linked to neutropenia.