Strikingly in this context, mesenchymal stromal cells (MSCs), osteolineage cells (OLCs), and endothelial cells in neutropenia, like HSCs, displayed reduced expression of Iigp1 and the transcriptional signatures indicative of activated IFN signaling (Fig. 4B, C, Supplementary Data 1). Here, IFNA1 is linked to Decreased total neutrophil count.