CD274 and neoplasm: Low antigen presentation by dendritic cells (DCs), immunosuppression of tumor-associated macrophages (M2-type macrophages), and the inactivation of programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1) immunosuppressive pathway, mainly contribute to reduce the effectiveness of T cell-triggered immune responses [7–9].